Effects of a MMDA on the health and performance of weaned pigs under combined dietary exposure to DON and ZEN

 OBJECTIVE 

The aim of this study was to evaluate the efficacy of a multicomponent mycotoxin detoxifying agent (MMDA, MYCORAID) in weaned pigs receiving feed contaminated with deoxynivalenol (DON) and zearalenone (ZEN).

 MATERIALS & METHODS 

In total, 168 pigs were equally allocated in four experimental groups from day 25 to day 66 of age.

  • T1 group: pigs that received feed without mycotoxins or MMDA.
  • T2 group: pigs that received contaminated feed with 1.5 mg of DON/kg feed and 0.9 mg of ZEN/kg feed for the first two weeks and 1.2 mg of DON/kg feed and 0.9 mg of ZEN/kg feed for the rest of the trial period, without the addition of MMDA.
  • T3 group: pigs that received the contaminated feed with the addition of 1.5 g of MMDA/kg feed.
  • T4 group: pigs that received the contaminated feed with the addition of 3 g of MMDA/kg feed.
Performance parameters, stress, and inflammatory biomarkers, as well as mycotoxin residues in liver, kidney, and muscle tissue were assessed.

 RESULTS 

The results demonstrated improved average daily gain (ADG) and feed conversion ratio (FCR) along with reduced DON residues in kidney samples in groups T3 and T4 when compared with T2 group.

Although a typical dose–response relationship was not present in all parameter alterations, the results of the study proved the efficacy of MYCORAID with improved growth performance and reduced mycotoxin absorption under the concurrent DON and ZEN exposure conditions and supported its use as a mitigating tool against mycotoxicosis under field conditions.

Authors

Jog Raj1*, Panagiotis Tassis2*, Klaus Männer3, Hunor Farkaš1, Zdenka Jakovčević1 and Marko Vasiljević1

1Patent Co, DOO., Vlade Ćetkovića 1A, 24211 Mišićevo, Serbia; [email protected] (H.F.); [email protected] (Z.J.); [email protected] (M.V.)
2Farm Animals Clinic, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece
3Institute of Animal Nutrition, Freie Universität Berlin, Germany; [email protected]

**Correspondence: [email protected] (J.R.); [email protected] (P.T.)

Micotoxicosis prevention
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