Efficacy of a modified clinoptilolite-based adsorbent against the detrimental effects of Ochratoxin A in laying hens

OBJECTIVE

The aim of this study was to evaluate the efficacy of modified clinoptilolite (Minazel Plus^®) as a mycotoxin adsorbent for mitigating the effects of ochratoxin A (OTA) on the performance of laying hens and OTA-associated pathohistological changes, as well as the presence of OTA residue in their eggs.

MATERIALS & METHODS

Forty-eight laying hens (27 weeks old) were equally divided into six groups and allocated to the following experimental treatments for 7 weeks:

Control group: without feed additive
Grupo MZ: 0.2% of Minazel Plus^®
Grupo E-I: 1 mg/kg OTA
Grupo E-II: 0,25 mg/kg OTA
Grupo E-III: 1 mg/kg OTA + 0.2% of Minazel Plus^®
Grupo E-IV: 0.25 mg/kg OTA + 0.2% of Minazel Plus^®

RESULTS

Overall, the addition of 0.2% Minazel Plus^® in laying hens feed mitigated the harmful effects of OTA on target organs and reduced the presence of OTA residues in eggs.

The groups that received 0.2% of Minazel Plus^® achieved better production results in terms of body weight, number of eggs, and feed consumption, compared to the other treatments.

The current findings confirm the efficacy of Minazel Plus^® in preventing performance losses in laying hens exposed to OTA, as well as for improving the welfare and health of food producing animals.

Authors

Marko Vasiljević¹, Darko Marinković², Dragan Milićević³, Jelka Pleadin⁴, Srđan Stefanović³, Saša Trialović⁵, Jog Raj⁶, Branko Petrujkić⁷ y Jelena Nedejković Trialović⁷

¹Faculty of Veterinary Medicine, University of Belgrade, Serbia
²Department of Pathology, Faculty of Veterinary Medicine, University of Belgrade, Serbia
³Institute of Meat Hygiene and Technology, Belgrade, Serbia
⁴Croatian Veterinary Institute, Laboratory for Analytical Chemistry, Zagreb, Croatia
⁵Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Belgrade, Serbia
⁶Patent Co, DOO., Mišićevo, Serbia
⁷Department of Animal Nutrition and Botany, Faculty of Veterinary Medicine, University of Belgrade, Serbia

References

Vasiljević, M.; Marinković, D.; Milićević, D.; Pleadin, J.; Stefanović, S.; Trialović, S.; Raj, J.; Petrujkić, B.; Trialović, J.N. Efficacy of a Modified Clinoptilolite Based Adsorbent in Reducing Detrimental Effects of Ochratoxin A in Laying Hens. Toxins 2021, 13, 469. https://doi.org/10.3390/toxins13070469