Effect of MINERAL ADSORBENTS
in POULTRY PRODUCTION

The quality of poultry feed is an important prerequisite to achieve optimal production results, and the preservation of the health status of animals, especially in intensive livestock production, hence it is necessary to control both raw materials and finished feed mixtures.
The presence of fungi (moulds) in food for animals is a natural phenomenon, not an exception.

Sources of contamination of poultry feed with fungi and resulting mycotoxins vary, starting with raw materials (e.g. corn as the most common component) during harvest and transport, during storage of raw materials and finished products, as well as in the production process and manipulation of poultry feed.

D. Karanovic1, V. Djermanovic2, S. Mitrovic2, V. Radovi1, D. Okanovic3, S. Filipovic3 y V. Djekic1
1Department of Animal Husbandry, Faculty of Agronomy, University of Kragujevac, Cacak, Serbia 2Institute of Zootechnic, Faculty of Agriculture, University of Belgrade, Belgrade (Serbia) 3Institute for food technology in Novi Sad (Serbia) 4Center of Small Grains, Kragujevac, (Serbia)
Zeolita

MINERAL ADSORBENTS

Mineral adsorbents are increasingly used in poultry production, especially in the nutrition of various types and categories of poultry, to control fungal contamination.
Using different mineral adsorbents in poultry nutrition can prevent the losses due to mycotoxicosis. It can also prevent:
  • Appearance of toxic residues in poultry products
  • Improve production and reproductive ability of birds
  • Contribute to improving the quality of poultry products
The use of mineral adsorbents in poultry feeds has application in neutralising the harmful effects of mycotoxins in buildings where poultry is reared.

Datas introduction

According to official data from global institutions such as the FAO, at least 99 countries in the world, which contain approximately 87% of the world population, have some kind of regulation for the content of mycotoxins in food for humans and/or animals.
Worldwide interest in these problems is reflected in the vast number of scientific and professional papers published on mycotoxins since the discovery of aflatoxin B1 in the early 1960’s.
Given the ubiquitous nature of moulds, as well as the general impossibility to prevent mycotoxin contamination in foods feed materials, this topic is an integral part of modern livestock production.
The increase in irregularity of meteorological conditions associated with global climate change has increased the problems of fungal contamination at harvest and the production of toxins.
Although it is almost impossible to examine and measure the true impact of moulds and mycotoxins, the risks associated with the presence of mycotoxins is well researched and proven.
Mycotoxins

Mycotoxins

Mycotoxins are toxic secondary metabolites of a large number of saprophytic organisms (moulds), which, proliferate in contaminated food infested with spores, conidia and/or fragments of mycelium.
Fungal toxins entering the body of animals and humans via the gut cause intoxication, generally called mycotoxicosis.
Damage to livestock due to mycotoxicosis may be significant, and is manifested in the form of direct losses due to mortality of animals or, more commonly, caused indirectly due to falling production and reproductive performance (Ožegović, 1983).
A specific problem is the mycotoxin residues found in different quantities in edible organs and animal products, which enter the foodchain and may cause adverse effects in humans.

Mycotoxins properties

In chemical terms, mycotoxins represent a wide range of complex compounds with different functional groups and therefore different properties:
  • Mycotoxins do not have sufficiently large molecules, and human and animal organisms do not produce antibodies against them and so remain permanently unprotected from their action
  • There is no simple method for their identification

Most frequent mycotoxins in food

Common mycotoxins in foods include:
  • Aflatoxins
  • Ochratoxin
  • Fusarium toxins (zearalenone, trichothecenes)
  • Ergot alkaloids
  • Sterigmatocistin
  • Patulin
  • Penicillanic acid
  • Rubratoksins
  • Sporodezmins
Zeolitas

Zeolites

Semmens (1983) state that zeolites, as mineral adsorbents, in accordance of their structure, are part of the alumina silicates group (SlO4 and AlO4), where the tetrahedral structure (TO4) is the basic unit.

Zeolite structure

Tetrahedrons may contain various bonds, giving the zeolite structure many channels and cavities.
TThe channel system may be One-dimensional (unconnected parallel channels) Two-dimensional (channels connected in one plane) and Three-dimensional.
The diffusion rate of adsorption and ion exchange are functions of the spatial channels distribution.
Every mineral is characterised by the channel opening size, so zeolites selectively retain or lose molecules depending on their dimensions.
Zeolitas

Negative charge

The negative charge of the threedimensional network, which is conditioned with tetrahedral coordination, is characteristic of all the zeolites, with respective isostructural substitution of Sl4+ ions with Al3+ ions.
The surplus negative charge is compensated for by univalent and/or divalent cations which are located in the channels and cavities.
The presented ions do not enter the zeolite tetrahedron network and, with the ion exchange reaction, they can be replaced by cations of other metals.
The cation exchange capacity of zeolites is a function of silicon substitution with aluminium in the tetrahedron network.
More alkali cations are required to compensate for the negative charge of elementary cells if the degree of substitution is higher.
The cation exchange capacity for natural zeolite is dependent on the dimensions of the channels, ionic shape and size, the charge density and ionic valency from the electrolyte composition and is in the range of 200-300 mEq/100g in zeolites (Dixon y Weed, 1989).

Clinoptilolite supplementation in feed

Boyer (2000) states that clinoptilolite supplementation in animal feed leds to a significant increase in feed efficiency as well as reducing the potential of intestinal diseases (diarrhoea), and the toxic effects of surplus ammonium ions.
Some researchers explain this as the clinoptilolite preference for large ions, such as NH4+, so it serves as a reservoir for ammonia. Some natural zeolites adsorb mycotoxins from feedstuffs and offer some protection from their toxic affects during digestion.
Clinoptilolite
Mixing process
The process of mixing is an important phase in the production of premixes and feeds, in order to attain uniformity in the basic matrix (carrier) distribution of the components so that each consumed amount of feed contains the required amount of nutrients (Filipović et al., 1993), including toxin binders.
Spoilage of animal feed means deviation from the normal quality in terms of changes of organoleptic characteristics, nutritional value and/ or hygiene of food stuffs (Šefer et al., 1997).
Feed contamination with fungi causes poorer productive performance, increased metabolic disorders and diseases, and can eventually cause death. As a result, the presence of moulds in animal feed is an important criterion in evaluation of the quality of an animal feed. Zeolitas
Feed samples
In Serbian conditions, feed samples commonly contain zearalenone, ochratoxin A, trichothecenes (T-2, DAS) and aflatoxins.
Research by Bočarov-Stančić et al. (2000) and Jajić et al. (2010) showed that in years with good climatic conditions, between 20 and 25% of cereals were contaminated with mould and mycotoxins. Rajić and Ožegović (1990) suggested a set of measures for the prevention and control of moulds in corn, namely:
  • The selection of corn resistant to mould
  • Seeding early varieties
  • Prevention of grain breakage
  • Artificial grain drying
  • Hygienic cleaning of the grain hoppers
  • Grain aeration
  • Tighter control measures for moisture
  • Treating grain with propionic acid or a mixture of organic acids
Adsorbent in Poultry production
In intensive poultry production adsorbents most often used to neutralise the harmful effects of mycotoxins achieve this by bonding.
Adsorption is one of the most important and common methods in preventing mycotoxicosis.
Some of the adsorbents used include:
  • Activated charcoal
  • Hydrated sodium-aluminosilicates calcium (HSCAS)
  • Bentonite
  • Clay soil
  • Various aluminosilicates or zeolites (Adamović et al., 2003; Resanović et al., 2004)
Zeolites are classified as safe or GRAS (Generally Regarded As Safe) compounds as per EU 21 CFR Part 582.2729.
Supplementing zeolites
Supplementing zeolites at a rate of 0.5% in poultry feed under field conditions has achieved good results in the prevention of mycotoxins.
Further research on the different categories of poultry showed that zeolites can be used in amounts of 0.2% of the feed to effectively prevent the harmful effects of mycotoxicosis (Radović et al., 2000), which confirmed the previous results obtained in vitro.
Adding 0.5% of the commercial zeolite ‘Min-a-Zel’(MZ) in feed for laying hens contaminated with T-2 toxin (2 mg/kg in corn and 1.2 mg/kg in sunflower pellet) had a positive impact on increasing laying capacity and mitigated the negative effects of T-2 mycotoxicosis.
The research using MINAZEL in hens diets, supplemented at levels of 0, 0.2, 0.3 and 0.5%, confirmed that the best performance was with 0.5% MINAZEL, giving increased laying, higher egg weight, better feed intakes, less feed consumption per egg, and improved FCR (Radović, 1997; Radović et al., 2000).
The use of MINAZEL at a level of 0.2% in broilers diets had a positive impact on reducing mortality, achieving higher body weights and improving FCR (Palić et al., 1990; 1991; Radović et al., 1999; 2003; 2004).
Bočarov-Stančić et al. (2000) added zeolites into meal feeds for broilers and found enhanced growth of 1.7-2.6%, and better FCR by 5.9-6.4% in the supplemented compared to the control group.
Zeolite (clinoptilolite) supplemented at levels of 1.2% and 4% in feed had a positive effect on weight gain, final body weight and FCR in broilers, with the best performances seen in those receiving the 2% zeolite feed.
Adding MINAZEL at a level of 0.5% had a positive impact on body weight and growth of broilers and prevented the deposition of aflatoxin B1 in organs (Sinovec and Resanovic, 2005; Resanović and Sinovec, 2006).

Studies

The effects of different types and levels of mineral adsorbents (MINAZEL and ‘Min-a-Zel Plus’ (MZ+)) on production and slaughter characteristics of broilers at 42 days were studied by Karović (2009), Karović et al. (2010) and Radovic et al. (2010a; 2010c).

During the fattening stage, different zeolites at different levels were used and compared to a negative control; MINAZEL at 0.5%; MINAZEL PLUS at 0.2% and MINAZEL PLUS at 0.3% inclusion.
The authors concluded that the maximum weight gain was seen at 0.5% inclusion, and the percentage of inedible products was highest in the 0.2% group.
Radović et al. (2010a) examined the impact of different levels of mineral adsorbents (MINAZEL and MINAZEL’) added to broiler feed on production.

A trial was conducted with 400 broilers from one day old, of Cobb 500 breed, divided into four experimental groups. The control group (K) and experimental groups (I, II and III) were fed a complete feed of the same composition, with different levels of added mineral adsorbent (0.5, 0.2 and 0.3% respectively).

The authors showed that 0.5% supplementation gave the best feed conversion (1.716 g/g), followed by 0.3% (1.891 g/g) and 0.2% (1.978 g/g), with the poorest seen for the control group (2.161 g/g). In addition, the highest average body weights, average daily gains, and best FCR was observed for the 0.5% group.

The authors concluded that broilers fed complete feeds with 0.5% clinoptilolite gave better results, and that the differences between the mid values were statistically significant (P< 0.05).
Broilers

Similar studies were conducted by Radović et al. (2009; 2010b) who explored the influence of the addition of the mineral adsorbents MINAZEL and MINAZEL PLUS to feed on the yield of broiler chickens separated by gender.
The research was conducted on 400 Cobb 500 broilers, divided into four treatment groups, until they were 42 days of age.
Dietary treatments included a control (0%), 0.5% MINAZEL, 0.2% MINAZEL PLUS and 0.3% MINAZEL PLUS.
  • The highest mortality was seen in the control group
  • The lowest mortality: in the experimental group with the addition of 0.3% ‘ MINAZEL PLUS.
Broilers
Average body weight
  • The highest average body weight of chickens were in the 0.5% group (♂ 2179.8 g, ♀ 2086.3 g).
  • Weight gain of chickens fed 0.3% MINAZEL PLUS ranged between 1976.5 g (♂) and 1899.3 g (♀).
  • The average weight of chickens fed 0.2% MINAZEL PLUS was 1874.8 g (♂) and 1836.0 g (♀).
  • The chickens in the control group had the lowest weights (♂ 1754.5 g, ♀ 1649.0).
Weight of chilled carcasses
  • Best total weight of chilled carcasses was found in the 0.5% supplemented group of chickens (♂ 1570.0 g, ♀ 1510.0 g)
  • Followed by 0.3% (♂ 1428.8 g, ♀ 1371.3 g),
  • 0.2% (♂ - 1358.8 g, ♀ - 1303.8 g)
  • Control (♂ - 1265.0 g, ♀ - 1176.3)
Broilers
The lowest yield (71%) was found in female broilers in the 0.2% group, while the highest value of 72.5% was in the same treatment of male broilers.

Palić et al. (1990) conducted a trial using one-day old chickens, divided into three groups of 50 animals.
One experimental group received T-2 toxin at a level of 1 mg/kg body weight directly into the crop.
The other groups received the same treatment, but with the addition of 0.2% MINAZEL into the feed.
The group that received the MINAZEL achieved the highest average body weight (899 g) compared to the chicks that did not receive the mycotoxin adsorbent (805 g).

In a further experiment with broilers, (Palić et al., 1991) zeolite supplement in doses of 0, 0.2, 0.5, and 1.0% in feed contaminated with 5.0 and 5.4 mg/kg zearalenone.
It was determined that 0.2% MINAZEL gave the best results, showing the lowest mortality, highest weight and lowest average feed consumption per kg gain.

In a study with 100 broilers divided into four groups of 25 animals, a complete diet either without zeolite (control) or with the addition of 0.2%, 0.5% and 1% zeolite.

Rajić et al. (1992) found that:
  • The average weight of the experimental groups, compared to the control, on the 35th and 40th day of age were significantly higher (P< 0.001).
  • FCR, relative to the control group, was 3.4% lower for the 0.2% group, 3.66% for the 0.5% group and 3.70% for the 0.1% group.
Based on these results, the authors concluded that the addition of zeolite to feed for chickens had a positive impact on body weight and feed conversion.
In a dose response trial for zeolite (0, 2.5 and 5%) Rajić et al. (1992) found that chickens fed 2.5% supplemented feed had 9% higher body weights and 4-8% improved feed conversion.
Kelemen and Bogaromy (1983) fed broiler chickens with a feed containing 3% and 10% zeolite.
The 3% diet had less influence on body weight than that supplemented with 10% in the final (grower) stage of feeding. Average chicken body weight on day 49 was 3.5% to 4% less in the control chickens group.
In addition, Duff et al. (1987) found that mycotoxins that cause inhibition of growth can also cause a reduction in bone strength.
It is considered that the presence of even minimal amounts of OTA (> 0.5 ppm) can cause a negative effect on the broiler performance.
These negative effects are already evident at the end of the first week of age, when fed contaminated feed, and chicks then lag behind in growth, which is dose dependent, but which is more pronounced in males.
Exposure to contaminated feed without supplementation with a mineral adsorbent for longer periods causes a significant decrease in body weight (~ 12%) and increased feed conversion ratio.
The results for average daily gains in broilers show that mycotoxins cause significantly negative effects on this parameter. Ayed et al. (1991) found significantly lower daily weight gains in broilers fed contaminated feeds without adsorbent supplementation.

Valdivia et al. (1993) found that the addition of 5% zeolite stimulated the growth of broilers fattened to 49 days.
Similarly, Talanov et al. (1994) noted that 3% of zeolite or 3% zeolite plus 0.04% methionine, significantly (P< 0.05) affected daily gain compared to the control group.
Similar studies with 5% zeolite supplementation in broiler feed was carried out by Karelin (1985) who found that the average chicken gains were 1593 g for the supplemented group versus 1528 g for the control group. The percent of live chickens was 91.1 and 96.5 respectively.
Sukan et al. (1994) added 1% of zeolite to broiler feed which was not contaminated with mycotoxins. Results showed that body weight of chicks and daily gain were increased with zeolite, but also caused higher (poorer) feed conversion.
Similar tests were conducted by Dobeic and Amon (1994), where clinoptilolite was added in quantities of 1, 2, 4 and 6% to feed. Clinoptilolite at 1, 2 and 4% resulted in increasing gain, higher final body weights and better feed conversion. Clinoptilolite increased the number of erythrocytes in the blood, while the 6% inclusion level led to decreased moisture in the faeces. Furthermore, the addition of 1% zeolite in feed reduced aflatoxin B1 residues by 72%, although 2% zeolite gave the same levels of residues as the control group (no aflatoxins), with gain improvements of 1.7-2.6%, and better feed utilisation of 5.9-6.4%.
The use of zeolites (clinoptilolite) in various amounts (1, 2, 4 and 6%) showed that feeding 1, 2 and 4% had a positive effect on body weight gain and final weight of broiler chickens.
The highest body weight and feed conversion efficiency were in the group of broilers fed 2% zeolite in the ration.

Závodský et al. (1985) fed males and females with 1% and 2% of zeolite in feed.
  • On the 50th day of feeding, the body weight was 1803 g and 1819 g (with 1% or 2% of zeolite respectively).
    The body weight of chickens fed the negative control was 1873 g.
  • Feed conversion in which the zeolite was added was 2.36 and 2.184, and without zeolite it was 2.00.
Broilers
Lon-Wo et al. (1987) fattened chickens with feed containing 5% of zeolite for a period of eight weeks.
They determined that the fattening production results at the beginning of the trial in both groups of chickens were very similar, but at the end of trial period, feed efficiency was better and mortality lower for the broilers which received zeolite (P< 0.05).
Addition of 5% zeolite in the finishing feed for chickens gave significant improvements in feed conversion (P< 0.05).
In a second experiment, 20 geese aged 7-21 days old were fed a ration contaminated with aflatoxin B1, B2 and G1 concentrate, with and without zeolite. Zeolite addition improved conversion and carcass yield.
Application of zeolite in feed to prevent poultry mycotoxicosis has been shown to be effective (Sinovec et al., 2002; Radović and Bogosavljević-Bosković, 2006) both in experimental (Resanović et al., 2004), and practical conditions (Palić et al., 1991).
  • Adding zeolite in feed contaminated with different mycotoxins reduces pathomorphological alterations in target organs (Nedeljković-Trailović et al., 2001; 2004).
  • In addition, significant reductions in the presence of residues in edible tissues of broilers have been noted (Sinovec et al., 2002).
  • But it should be stated that the efficiency of zeolite depends on the application and form in which it is used (Radović et al., 2000; Resanović et al., 2004).

Conclusions

It is assumed that different levels of mineral adsorbents added to the feed of broiler chickens have different and unequal effects on consumption and feed conversion, body weight gain, final body weights, carcass traits and meat quality as well as the health status of chickens in accordance with duration and economic performance.
Tica et al. (2010) also demonstrated the impact of zeolites on the economic performance of growing broiler chickens exposed to mycotoxins.
The use of mineral adsorbents in feeds and premixes can provide a solution to mycotoxicosis, showing better productive performance and economic returns to growers.

However, in Serbia, the full benefits of the use of mineral absorbents can only be seen with the readiness of customers to purchase poultry meat products according to their quality.
Increasing needs of consumers for improved food safety and quality impose constant problems in producing suitable and acceptable poultry meat and eggs. Mycotoxin contamination of animal feed and resulting residues in meat and eggs are therefore an important consideration in poultry production.
Because mineral adsorbents are broadly used in poultry diets, they contribute greatly in improving the quality of feedstuffs, productive performance, meat quality and carcass yield.

For egg production, adsorbents can help increase egg production in laying hens, reduce mortality, improve feed conversion and prevent the occurrence of various pathological changes.

Acknowledgements The authors are grateful to the Ministry of Education and Science of Republic of Serbia, for sponsoring part of the study in project № TR – 31033 and TR – 20066.


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Micotoxicosis prevention
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